So, this one’s going to be a snooze-fest. You are forewarned. For the scientifically-inclined, maybe this is fun stuff for you.
I got the specific results of my immune testing in the mail today. Dr. S had told me over the phone that I have activated T cells. Well, more specifically, my immunophenotype testing showed that I have high levels of:
- CD8+ (cytotoxic T lymphocytes) – level is 52 (normal is 19-48)
- CD5+ (B cells) – level is 13 (normal is 0-8)
So, my problem is an autoimmune problem. It’s interesting that immune problems are genetically related. Many people who have immune issues will find that they exist in their family. For example, my grandmother has a thyroid problem and my dad has plantar fasciitis. Also, I have had my own autoimmune issues in the past with HPV, which caused cervical dsyplasia.
Lymphocytes, particularly B-cells, T-cells (helper and suppressor) and killer (NK) cells have been the focus of intense research interest to the discipline of reproductive immunology. Immunophenotype refers to the relative amounts of T, B and NK cells in the bloodstream. (From RIA lab.)
CD8+ (cytotoxic T lymphocytes)
These are also called activated T cell or killer T cells. CD8 T cells efficiently eliminate infected and abnormal cells. In the case of repeat pregnancy loss, they become overly aggressive and go after the wrong targets.
CD5+ (B cells)
B cells may be of two subtypes known as B-1 and B-2 cells. When we examine a second surface-displayed marker on CD19 expressing cells known as CD5, the cells are classified at B-1 B cells. They represent a class of B cells that is involved in autoimmune disorders (conditions where the body mounts an immune response against a body tissue). Women with elevations of these cells may be at risk for thyroiditis and the premature menopause. (From ReproMed.net)