Education, Infertility

Lovenox Injections Tips

June 28, 2010

I just recently started Lovenox injections after becoming pregnant because I have Factor V Leiden disorder and low anti-thrombin III and protein S levels.   The shots have turned out to be pretty dreadful.  In fact, it is the worst injection I’ve had to endure to date, including the progesterone in oil shots in the hip.    The medicine really hurts going in, hurts afterward as well and tends to bruise really bad!

What it feels like (for me)

  • Burning, aching, throbbing all at once
  • Feels like you’re being injected with tiny little daggers
  • Feels like someone is pressing on a wound

There are different schools of thought on how to inject these, but here’s what I’ve discovered personally and from talking to others.

Here’s what you need to know:

  • Get the air bubble out by flicking it pretty hard several times and then pushing up to get it out.
  • Make sure there is no liquid on the needle.  If necessary, use your alcohol pad to wipe it by running it along side of the  needle.  This should help with the bruising.
  • Pick a spot on your belly in the love handle area. It says to inject at least two inches away from your belly button, but two inches away really hurt me.  I would recommend even farther away, closer to your side because it won’t hurt as much.
  • Wipe skin with alcohol pad.
  • Make sure to inject with the cut side up.
  • Pinch an inch and inject the needle all the way in as far as it will go. I think this helps with bruising as well.
  • Here’s where it really differs for each person.  Try injecting fast and try it slow.  Some have said that doing it slow makes it more tolerable for them.  I have tried both ways.  For me, it hurts either way, so I’d rather go fast.
  • Pull the needle out as straight as you can and let go of the skin.
  • Wipe with alcohol pad or apply pressure if bleeding.
  • DO NOT MASSAGE!  This will cause even worse bruising.
  • Lay down for a few minutes until the pain subsides.  I use a little icepack on the injection site right after and that helps. These little ice packs are perfect.


These tips have helped me a lot.  We ended up getting really good at doing these, and were able to avoid the bruising and lessen the pain.  In the beginning, I could not even imagine doing these every day, but it really did get better.


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  • Marianne

    I just wanted to let you know this was really helpful for me! I also really appreciate your list of testing to do for recurrent miscarriage. Thanks and congrats on your twins!

  • Kathy

    Iam on my second month of lovenox and my stomach is sore and bruised and has knots under the injection site. I will try the ice and see if that helps thank you for the tips.

  • Bridgit

    I’m not sure if you still monitor this post, but I just started injections two days ago and am not loving it. Day 1 went pretty fine, day to left me with a lump and a giant bruise, not looking forward to the shot tonight and only 260 or so days to go…so I really appreciate the tips! A question about one of them though: Make sure to inject with the cut side up…what do you mean by cut side?

    • Whitney Anderson

      UGH LOVENOX!!! So, it’s been so long I don’t specifically remember the why on this one, but mine had one side of the tip of needle that was lower, so that side up. Not sure if it’s still like that.